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Home - Products - Metabolic Enzyme/Protease - MMP - PF-00356231 hydrochloride

PF-00356231 hydrochloride

CAS No. 820223-77-6

PF-00356231 hydrochloride( —— )

Catalog No. M26367 CAS No. 820223-77-6

PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-00356231 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.
  • Description
    PF-00356231 hydrochloride is an inhibitor of matrix metalloproteinase MMP-12 with IC50 of 1.4 μM.(In Vitro):PF-00356231 hydrochloride shows potency against MMP-13, MMP-3, MMP-9, and MMP-8 with IC50s of 0.65 nM, 0.39 μM, 0.98 μM, and 1.7 μM, respectively. PF-00356231 hydrochloride decreases the IC50 values of MMP-12 (0.014 μM) and MMP-13 (0.27 μM) in the presence AH.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    MMP
  • Recptor
    Autophagy| DPP-4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    820223-77-6
  • Formula Weight
    464.96
  • Molecular Formula
    C25H21ClN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (44.80 mM)
  • SMILES
    Cl.OC(=O)C[C@@H](NC(=O)c1cc(cs1)-c1ccc(cc1)-c1ccncc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. J Pharmacol Exp Ther. 2008 Apr;325(1):175-82.
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